Methods, apparatus, systems, and articles of manufacture to generate an asset workscope are disclosed. An example system includes an asset health calculator to identify an asset on which to perform maintenance based on generating a first asset health quantifier corresponding to a first asset health status, a task generator to determine a first workscope including first asset maintenance tasks, and a task optimizer to determine a second workscope including second asset maintenance tasks based on the first asset health quantifier and/or first workscope. The example system includes a workscope effect calculator to generate a second asset health quantifier corresponding to a second asset health status when the second workscope is completed on the asset, and to update the asset health calculator, task generator, and/or task optimizer to improve determination of first and/or second workscopes to improve the second asset health quantifier relative to the first asset health quantifier.