A care plan risk rating (CPR2) system and method enables physicians and other clinicians to manage patient health care plans remotely in response to patient input to generate CPR2 values. In one aspect, patients under care for a particular condition respond to a series of questions related to that condition. The questions may be weighted according to predetermined criteria which a physician or clinician may set. Based on the CPR2 values, the physician or clinician may alter a care plan for a patient or a group of patients. In one aspect, patients with CPR2 values in a predetermined range may be grouped into a cohort, and their care plans managed as a group.