- Patent Title: 3-(benzylamino)-4-(cyclohexylamino)-n-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 analogues as cell death inhibitors for treating e.g. stroke
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Application No.: US16967871Application Date: 2019-02-05
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Publication No.: US11339124B2Publication Date: 2022-05-24
- Inventor: Peter Vandenabeele , Tom Vanden Berghe , Koen Augustyns , Sam Hofmans , Pieter Van Der Veken , Lars Devisscher
- Applicant: VIB VZW , Universiteit Antwerpen , Universiteit Gent
- Applicant Address: BE Ghent; BE Antwerp; BE Ghent
- Assignee: VIB VZW,Universiteit Antwerpen,Universiteit Gent
- Current Assignee: VIB VZW,Universiteit Antwerpen,Universiteit Gent
- Current Assignee Address: BE Ghent; BE Antwerp; BE Ghent
- Agency: Amster, Rothstein & Ebenstein LLP
- Priority: GB1801943 20180207
- International Application: PCT/EP2019/052751 WO 20190205
- International Announcement: WO2019/154795 WO 20190815
- Main IPC: C07C311/39
- IPC: C07C311/39 ; C07D227/02 ; C07D295/027 ; C07D221/00 ; C07D241/04 ; C07D227/04
Abstract:
The present invention relates to 3-(benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 (Fer-1) analogues as cell death inhibitors by inhibition of ferroptosis and/or oxytosis for the treatment of stroke, myocardial infarction, diabetes, sepsis, the prevention of transplant rejection, neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, dementia with Lewy bodies and Friedreich's ataxia. The present invention further relates to pharmaceutical compositions of these compounds and discloses methods for making the compounds and the corresponding intermediate.
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