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公开(公告)号：US20240318194A1
公开(公告)日：2024-09-26
申请号：US18260975
申请日：2022-01-11
申请人： VIB VZW , UNIVERSITEIT GENT
IPC分类号： C12N15/82 , C07K14/415
CPC分类号： C12N15/8273 , C07K14/415 , C12N15/8261
摘要： The present invention relates to the field of plant molecular biology, more particularly to the field of agriculture, even more particularly to the field of improving the yield of plants. The present invention provides chimeric genes and constructs which can be used to enhance the yield in plants and crops.
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公开(公告)号：US20240299618A1
公开(公告)日：2024-09-12
申请号：US18667729
申请日：2024-05-17
发明人： Ester HOSTE , Maarten MEES , Wim THELEMANS
CPC分类号： A61L26/008 , A61L26/0023 , A61P17/02
摘要： The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions, such as wounds. The invention provides topical plasters and wound healing compositions. Specifically, the invention provides hydrogels compositions of glycyrrhizinic acid analogues. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
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公开(公告)号：US11964002B2
公开(公告)日：2024-04-23
申请号：US16489265
申请日：2018-02-28
申请人： VIB VZW , UNIVERSITEIT GENT
发明人： Nico Callewaert , Robin Vanluchene , Bram Laukens , Anna Depicker , Vikram Virdi
CPC分类号： A61K38/20 , A23K20/10 , A23L33/18 , A61K9/19 , C07K16/1232 , A23V2002/00 , A61K2039/505 , C07K2319/30
摘要： The present invention relates to the field of recombinant protein production in a host cell. More specifically the invention relates to the field of oral protein delivery. Specifically, the invention provides oral pharmaceutical formulations comprising the culture medium of a recombinant host secreting a recombinant protein. The resulting oral pharmaceutical formulations are useful for the treatment of gastro-intestinal and/or buccal disorders. Additionally, the oral pharmaceutical formulations are useful for prophylactic and vaccine purposes.
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公开(公告)号：US11891451B2
公开(公告)日：2024-02-06
申请号：US16612476
申请日：2018-05-09
申请人： VIB VZW , UNIVERSITEIT GENT
CPC分类号： C07K16/40 , A61K47/6871 , C07K2317/22 , C07K2317/41 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/92 , C07K2317/94
摘要： The present invention provides nucleotide sequences encoding polypeptides comprising immunoglobulin variable domains with engineered glycosylation acceptor sites. Specifically, the invention provides immunoglobulin variable domain proteins modified with selected glycans and specific glycan-conjugates thereof. Also provided herein are methods for the production of glycosylated immunoglobulin variable domains and glycan-conjugates thereof.
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公开(公告)号：US20240025980A1
公开(公告)日：2024-01-25
申请号：US18355629
申请日：2023-07-20
发明人： Nikolai KLEY , Jan TAVERNIER , Leander HUYGHE , Anje CAUWELS
IPC分类号： C07K16/18 , A61P35/00 , A61K31/704 , A61K38/19 , A61K38/21 , A61K39/395 , C07K14/525 , C07K14/56 , C07K16/28
CPC分类号： C07K16/18 , A61P35/00 , A61K31/704 , A61K38/191 , A61K38/212 , A61K39/3955 , C07K14/525 , C07K14/56 , C07K16/2815 , C07K16/2818 , C07K16/2827 , A61K2039/505
摘要： The present invention relates, in part, to chimeric proteins that bind a non-cellular structure and their use as therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the chimeric proteins and their use in the treatment of various diseases.
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公开(公告)号：US20230364049A1
公开(公告)日：2023-11-16
申请号：US18246585
申请日：2021-09-24
发明人： Massimiliano MAZZONE
IPC分类号： A61K31/26 , A61K39/395 , A61K39/00 , A61P35/00
CPC分类号： A61K31/26 , A61K39/3955 , A61K39/4646 , A61K39/4614 , A61P35/00
摘要： The invention is situated in the field of cancer treatment. In particular it relates to treatments comprising combining an inhibitor of the pyrimidinergic receptor P2Y6 and an immune checkpoint inhibitor. Further in particular, the treatment is of benefit for cancers poorly responding to immune checkpoint inhibitor therapy.
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公开(公告)号：US20230293728A1
公开(公告)日：2023-09-21
申请号：US18300693
申请日：2023-04-14
IPC分类号： A61K48/00 , C12N15/63 , C12N15/52 , A61K38/48 , C07K14/81 , C12N15/85 , C12N9/64 , C12N15/86
CPC分类号： A61K48/0058 , C12N15/63 , C12N15/52 , A61K38/4846 , C07K14/8121 , C12N15/85 , C12N9/644 , C12N15/86 , C12Y304/21022 , A61K48/00 , C12N2799/025 , C12N2799/027 , C12N2830/008 , C12N2830/15 , C12N2830/85 , C12N2750/14143
摘要： Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.
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公开(公告)号：US20230287131A1
公开(公告)日：2023-09-14
申请号：US18325283
申请日：2023-05-30
发明人： Nikolai KLEY , Jan TAVERNIER , Leander HUYGHE , Thomas WUEEST
IPC分类号： C07K16/28 , C07K14/525 , C07K14/505 , C07K14/52 , A61P35/00 , C12N15/62
CPC分类号： C07K16/2875 , C07K14/525 , C07K14/505 , C07K14/52 , A61P35/00 , C12N15/62 , C07K2319/33 , C07K2319/75 , C07K2317/569
摘要： The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.
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公开(公告)号：US20230287046A1
公开(公告)日：2023-09-14
申请号：US17800844
申请日：2021-02-19
CPC分类号： C07K7/08 , A61P35/00 , C12N15/85 , C12N2800/107
摘要： Aspects of the invention concern non-naturally occurring molecules capable of downregulating the amount or biological activity specifically of mutant or variant forms of a protein, as well applications thereof.
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公开(公告)号：US20230278982A1
公开(公告)日：2023-09-07
申请号：US18145909
申请日：2022-12-23
发明人： Bart VANDERHOYDONCK , Arnaud MARCHAND , Stephen L. GWALTNEY, II , Stéphane SPIESER , Wim SMETS , Aurélie CANDI , Matthias VERSELE , Georg HALDER
IPC分类号： C07D401/10 , C07D231/12 , C07D401/06 , C07D405/06 , C07D401/14 , C07D213/16 , C07D409/14 , C07D405/14 , C07D401/04 , C07D405/04 , C07D255/02 , C07D257/04 , C07D471/04 , C07D403/04 , C07D403/10 , C07D413/04 , C07D417/04 , C07D403/14 , C07D413/14 , C07D471/08
CPC分类号： C07D401/10 , C07D231/12 , C07D401/06 , C07D405/06 , C07D401/14 , C07D213/16 , C07D409/14 , C07D405/14 , C07D401/04 , C07D405/04 , C07D255/02 , C07D257/04 , C07D471/04 , C07D403/04 , C07D403/10 , C07D413/04 , C07D417/04 , C07D403/14 , C07D413/14 , C07D471/08 , C07B2200/09
摘要： The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.
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