The present application discloses a processing method, device, equipment and storage medium of a loop instruction, and relates to the fields of voice and chips. A specific embodiment is: acquiring a computer program including a first loop body, where the first loop body is generated according to a second loop body in a software code to be compiled, the first loop body includes a plurality of first loop instructions, the plurality of first loop instructions can be identified by a hardware structure of a computer device; in the case that the first loop body is detected, determining loop parameters of the first loop body according to the plurality of first loop instructions; acquiring the plurality of first loop instructions according to the loop parameters of the first loop body; executing the plurality of first loop instructions.