- 专利标题: Multispecific antibody constructs
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申请号: US15321055申请日: 2015-06-25
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公开(公告)号: US11345760B2公开(公告)日: 2022-05-31
- 发明人: Pallavi Bhatta , Emma Dave , Sam Philip Heywood , David Paul Humphreys
- 申请人: UCB BIOPHARMA SRL
- 申请人地址: BE Brussels
- 专利权人: UCB BIOPHARMA SRL
- 当前专利权人: UCB BIOPHARMA SRL
- 当前专利权人地址: BE Brussels
- 代理机构: Marshall, Gerstein & Borun LLP
- 优先权: GB1411320 20140625
- 国际申请: PCT/EP2015/064409 WO 20150625
- 国际公布: WO2015/197772 WO 20151230
- 主分类号: C07K16/46
- IPC分类号: C07K16/46
摘要:
The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.
公开/授权文献
- US20170204200A1 MULTISPECIFIC ANTIBODY CONSTRUCTS 公开/授权日:2017-07-20
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