公开(公告)号：US20230087378A1

公开(公告)日：2023-03-23

申请号：US17786996

申请日：2020-12-18

Applicant: UCB BIOPHARMA SRL

Inventor： Adnan Rahman Khan ,  Sam Philip Heywood ,  David Paul Humphreys ,  Daniel John Lightwood ,  Emma Dave ,  Emily Mary Cairistine Barry ,  Sarah Jayne Stanyon

IPC: C07K16/24 ,  A61P37/08

Abstract: The present invention relates to a multi-specific antibody having specificity for human IL-13, human IL-17A and/or human IL-17F. The invention further relates to methods for producing the multi-specific antibody and to its therapeutic use for the treatment of atopic dermatitis and other diseases.

公开(公告)号：US11345760B2

公开(公告)日：2022-05-31

申请号：US15321055

申请日：2015-06-25

Applicant: UCB BIOPHARMA SRL

Inventor： Pallavi Bhatta ,  Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys

IPC: C07K16/46

Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.

公开(公告)号：US11786593B2

公开(公告)日：2023-10-17

申请号：US17078127

申请日：2020-10-23

Applicant: UCB BIOPHARMA SRL

Inventor： Sam Philip Heywood ,  Gavin Barry Wild ,  Razwan Hanif ,  Christopher John Le Page

IPC: A61K39/395 ,  C07K1/113 ,  C07K16/28 ,  C07K16/18 ,  C07K5/12 ,  C07C323/12 ,  C07C323/25

CPC classification number: A61K39/39591 ,  C07K1/1133 ,  C07K1/1136 ,  C07K16/18 ,  C07K16/2878 ,  C07C323/12 ,  C07C323/25 ,  C07K5/123 ,  C07K2317/31

Abstract: The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or Guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

公开(公告)号：US20220267476A1

公开(公告)日：2022-08-25

申请号：US17734253

申请日：2022-05-02

Applicant: UCB BIOPHARMA SRL

Inventor： Pallavi Bhatta ,  Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys

IPC: C07K16/46

Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.

公开(公告)号：US11091542B2

公开(公告)日：2021-08-17

申请号：US16063133

申请日：2016-12-14

Applicant: UCB BIOPHARMA SRL

Inventor： Ralph Adams ,  Pallavi Bhatta ,  Emma Dave ,  Sam Philip Heywood ,  David Paul Humphreys ,  Diane Marshall ,  Daniel John Lightwood

IPC: C07K16/24 ,  C12N15/63 ,  A61K39/00

Abstract: The invention relates to antibody molecules having specificity for TNF alpha, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：US10927164B2

公开(公告)日：2021-02-23

申请号：US15566231

申请日：2016-04-20

Applicant: UCB BIOPHARMA SRL

Inventor： Sam Philip Heywood ,  Gavin Barry Wild

IPC: C07K16/06 ,  C07K1/22 ,  C07K16/18 ,  C07K16/28

Abstract: The present invention provides a method for recovering a human VH3 domain-containing antibody in monomeric form. In particular the present invention provides a new method that allows recovery of monomeric human VH3 domain-containing antibodies from a mixture containing monomeric and multimeric forms of the antibody.

公开(公告)号：US11834514B2

公开(公告)日：2023-12-05

申请号：US17078130

申请日：2020-10-23

Applicant: UCB BIOPHARMA SRL

Inventor： Sam Philip Heywood ,  Gavin Barry Wild ,  Christopher John Le Page ,  Razwan Hanif

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/18

CPC classification number: C07K16/468 ,  C07K16/18 ,  C07K16/2878 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/624 ,  C07K2317/66

Abstract: The present invention provides method for increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one Fv with specificity for an antigen of interest comprising one VH and one VL wherein said VH and VL are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises a) a thermal conversion step of holding the composition comprising the antibody molecule at a temperature in the range 30 to 60° C. for a period of at least 1 hour, wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.

公开(公告)号：US20230242677A1

公开(公告)日：2023-08-03

申请号：US17787094

申请日：2020-12-18

Applicant: UCB BIOPHARMA SRL

Inventor： Emily Mary Cairistine Barry ,  Emma Dave ,  Sam Philip Heywood

IPC: C07K16/46 ,  C12N15/63 ,  C07K1/22

CPC classification number: C07K16/468 ,  C07K1/22 ,  C12N15/63 ,  C07K2317/31 ,  C07K2317/624

Abstract: Multi-specific Antibodies The present disclosure relates to a multi-specific antibody comprising or consisting of: a) a polypeptide chain of formula (I): VH-CH1-(CH2)-(CH3)-(X)-(V1); and b) a polypeptide chain of formula (II): (V3)-(Z) -VL-CL-(Y)-(V2) wherein the polypeptide chain of formula (II) comprises at least one dsscFv, dsFv, scFv, VH or VHH, and wherein the polypeptide chain of formula (I) comprises a protein A binding domain and wherein the polypeptide chain of formula (II) does not bind protein A. The disclosure also provides polynucleotide sequences encoding said multi-specific antibody, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. The disclosure also provides pharmaceutical formulations comprising same, for example for use in treatment. There is also provided a method of expressing a multi-specific antibody of the present disclosure from a host cell.