- 专利标题: Modified microorganisms comprising an optimized system for oligosaccharide utilization and methods of using same
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申请号: US15327616申请日: 2015-05-29
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公开(公告)号: US11345908B2公开(公告)日: 2022-05-31
- 发明人: Avram Michael Slovic , Daniel Johannes Koch
- 申请人: BRASKEM S.A.
- 申请人地址: BR Camaçari
- 专利权人: BRASKEM S.A.
- 当前专利权人: BRASKEM S.A.
- 当前专利权人地址: BR Camaçari
- 代理机构: Morgan, Lewis & Bockius LLP
- 国际申请: PCT/US2015/033286 WO 20150529
- 国际公布: WO2015/184327 WO 20151203
- 主分类号: C12N9/90
- IPC分类号: C12N9/90 ; C12N9/10 ; C12N9/12 ; C12P5/00 ; C12P7/06 ; C12P19/32
摘要:
The present disclosure generally relates to modified microorganisms comprising an optimized system for oligosaccharide utilization comprising one or more polynucleotides coding for one or more energy independent oligosaccharide transporters for transporting an oligosaccharide into the microorganism, one or more polynucleotides coding for enzymes that catalyze the conversion of the oligosaccharide into at least one phosphorylated saccharide, and one or more polynucleotides coding for enzymes that catalyze the conversion of the phosphorylated saccharide into an isomer of the phosphorylated saccharide that is utilized in one or more enzymatic pathways in the microorganism for the production of an organic molecule such as acetic acid, acrylic acid, 3-hydroxypropionic acid, lactic acid, etc. The present disclosure also generally relates to methods of using the optimized system for oligosaccharide utilization.
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