A transmission and distribution system with electric shock protection function includes a transmitting terminal and a receiving terminal. The transmitting terminal includes a switch, a current measurer, a signal generator, and a controller. The receiving terminal includes a filter. The switch is coupled to a first DC power and a transmission line. The current measurer is coupled to the transmission line, and measures a current of the transmission line and provides a current signal. The signal generator provides a disturbance signal to the transmission line. The controller receives the current signal and controls the switch. If the controller determines that the current signal contains the disturbance signal, the controller turns off the switch.