Invention Grant
- Patent Title: Process of preparing mRNA-loaded lipid nanoparticles
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Application No.: US16553747Application Date: 2019-08-28
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Publication No.: US11357726B2Publication Date: 2022-06-14
- Inventor: Shrirang Karve , Zarna Patel , Yi Zhang , Ashish Sarode , Rebecca L. Goldman , Frank DeRosa , Michael Heartlein
- Applicant: Translate Bio, Inc.
- Applicant Address: US MA Lexington
- Assignee: Translate Bio, Inc.
- Current Assignee: Translate Bio, Inc.
- Current Assignee Address: US MA Lexington
- Agency: Proskauer Rose LLP
- Main IPC: A61K9/12
- IPC: A61K9/12 ; A61K9/127 ; A61K9/14 ; A61K9/51 ; A61K31/7105
Abstract:
The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.
Public/Granted literature
- US20200085745A1 PROCESS OF PREPARING MRNA-LOADED LIPID NANOPARTICLES Public/Granted day:2020-03-19
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