公开(公告)号：US11964051B2

公开(公告)日：2024-04-23

申请号：US17054886

申请日：2019-05-15

Applicant: Translate Bio, Inc.

Inventor： Frank DeRosa ,  Shrirang Karve ,  Yi Zhang ,  Michael Heartlein

IPC: A61K9/127 ,  A61K9/00 ,  A61K38/18 ,  C07H13/06

CPC classification number: A61K9/1272 ,  A61K9/0019 ,  A61K9/0078 ,  A61K38/1816 ,  C07H13/06

Abstract: Disclosed are cationic lipids which are compounds of Formula (I′). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20220395459A1

公开(公告)日：2022-12-15

申请号：US17737712

申请日：2022-05-05

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Zarna Patel ,  Yi Zhang ,  Ashish Sarode ,  Rebecca L. Goldman ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K31/7105

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.

公开(公告)号：US20220133631A1

公开(公告)日：2022-05-05

申请号：US17450628

申请日：2021-10-12

Applicant: Translate Bio, Inc.

Inventor： Monic Shah ,  Travis Jeanotte ,  Yi Zhang ,  Shrirang Karve ,  Kimberly Gillis ,  Frank DeRosa

IPC: A61K9/127 ,  A61K31/7105

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing an mRNA solution containing low citrate concentration and a lipid solution at an ambient temperature. Thus, the present invention provides an effective, reliable, energy-saving and cost-effective method of encapsulating mRNA into lipid nanoparticles.

公开(公告)号：US20220071905A1

公开(公告)日：2022-03-10

申请号：US17291919

申请日：2019-11-07

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Yi Zhang ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K9/127 ,  A61K38/45 ,  A61K38/17 ,  C08G65/48

Abstract: The compounds disclosed herein (e.g., compounds having a structure according to Formula (I/(II)/(III)/(IV), and (V)) are polymers wherein an organic polymeric segment (e.g., a polyethylene glycol (PEG) group) comprises covalent attachments to two or more lipid substructures, and each lipid substructure independently comprises a hydrophobic moiety and a hydrophilic moiety. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20220016029A1

公开(公告)日：2022-01-20

申请号：US17291923

申请日：2019-11-07

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Yi Zhang ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K9/127 ,  C08G65/333 ,  C08G65/332 ,  C08G65/335 ,  A61K45/06

Abstract: The compounds disclosed herein (e.g., compounds of Formula (I), (II), (III), and (IV)) comprise a lipid substructure comprising a hydrophobic moiety and a hydrophilic moiety; and two or more polymeric groups (e.g., two or more polyethylene glycol (PEG) groups). The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20210220273A1

公开(公告)日：2021-07-22

申请号：US17058334

申请日：2019-05-30

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Shrirang Karve ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K9/127 ,  A61K9/00 ,  A61K39/385 ,  A61K38/45 ,  A61K38/52 ,  C07J41/00

Abstract: Disclosed are cationic lipids which are compounds of Formula I. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20250099384A1

公开(公告)日：2025-03-27

申请号：US18790052

申请日：2024-07-31

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Shrirang Karve ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K9/127 ,  A61K38/45 ,  A61K38/52 ,  C07C327/22 ,  C07C327/30 ,  C07D245/02 ,  C07D257/00

Abstract: Disclosed are cationic lipids which are compounds of Formula (I), (II), (III), (IV), (V), or (VI). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20240374521A1

公开(公告)日：2024-11-14

申请号：US18609160

申请日：2024-03-19

Applicant: Translate Bio, Inc.

Inventor： Frank DeRosa ,  Shrirang Karve ,  Yi Zhang ,  Michael Heartlein

IPC: A61K9/127 ,  A61K9/00 ,  A61K38/18 ,  C07H13/06

Abstract: Disclosed are cationic lipids which are compounds of Formula (I′). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20220233444A1

公开(公告)日：2022-07-28

申请号：US17605343

申请日：2020-04-21

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Yi Zhang ,  Frank DeRosa

IPC: A61K9/127 ,  C07C327/22 ,  A61K48/00 ,  A61K38/45 ,  A61K38/17

Abstract: The present invention provides, in part, thioester cationic lipid compounds of formula A, and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20220226244A1

公开(公告)日：2022-07-21

申请号：US17614096

申请日：2020-05-29

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Shrirang Karve ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K9/127 ,  A61K38/45 ,  A61K38/17 ,  A61K39/385 ,  C07D321/00 ,  C07D405/06 ,  C07D405/14 ,  C07D493/20 ,  C07C229/12 ,  A61K48/00

Abstract: Disclosed are cationic lipids which are compounds of Formula I. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.