Invention Grant
- Patent Title: Synthesis of tyrosine derived polyarylates
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Application No.: US16936858Application Date: 2020-07-23
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Publication No.: US11359050B2Publication Date: 2022-06-14
- Inventor: Satish Pulapura , Fatima Buevich , Xiangji Chen , Suping Lyu
- Applicant: MEDTRONIC, INC.
- Applicant Address: US MN Minneapolis
- Assignee: MEDTRONIC, INC.
- Current Assignee: MEDTRONIC, INC.
- Current Assignee Address: US MN Minneapolis
- Agency: Sorell, Lenna & Schmidt, LLP
- Main IPC: C08G63/81
- IPC: C08G63/81 ; C08G63/16 ; C08G63/685

Abstract:
A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.
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