A method of dynamic cache configuration includes determining, for a first clustering configuration, whether a current cache miss rate exceeds a miss rate threshold. The first clustering configuration includes a plurality of graphics processing unit (GPU) compute units clustered into a first plurality of compute unit clusters. The method further includes clustering, based on the current cache miss rate exceeding the miss rate threshold, the plurality of GPU compute units into a second clustering configuration having a second plurality of compute unit clusters fewer than the first plurality of compute unit clusters.