Invention Grant
- Patent Title: Compounds
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Application No.: US16501493Application Date: 2019-11-22
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Publication No.: US11364246B2Publication Date: 2022-06-21
- Inventor: Stephen Collingwood , Clive Mccarthy , Jonathan David Hargrave , Duncan Alexander Hay , Thomas Beauregard Schofield , Sarah Ellam , Craig Stephen Buxton , Matthew Habgood , Peter Neville Ingram , Chun Yan Ma , Spencer Charles Robert Napier , Abdul Kadar Shaikh , Matthew Raymond Smith , Christopher Charles Stimson , Edward Richard Walker
- Applicant: TMEM16A Limited
- Applicant Address: GB Brighton
- Assignee: TMEM16A Limited
- Current Assignee: TMEM16A Limited
- Current Assignee Address: GB Brighton
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Main IPC: C07D413/12
- IPC: C07D413/12 ; A61K31/5377 ; A61K31/167 ; A61K31/351 ; A61K31/4025 ; A61K31/4045 ; A61K31/416 ; A61K31/44 ; A61K31/443 ; A61K31/4439 ; A61K31/444 ; A61K31/498 ; A61K45/06 ; C07C233/76 ; C07D209/18 ; C07D213/81 ; C07D231/56 ; C07D309/14 ; C07D401/12 ; C07D405/12 ; C07D409/12
Abstract:
Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R* X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.
Information query
