Invention Grant
- Patent Title: Neuronal enhancers
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Application No.: US16181723Application Date: 2018-11-06
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Publication No.: US11364309B2Publication Date: 2022-06-21
- Inventor: Justin Cotney , Clifford Kentros , Stefan Blankvoort , Rajeevkumar Raveendran Nair
- Applicant: Norwegian University of Science and Technology (NTNU) , University of Connecticut
- Applicant Address: NO Trondheim; US CT Farmington
- Assignee: Norwegian University of Science and Technology (NTNU),University of Connecticut
- Current Assignee: Norwegian University of Science and Technology (NTNU),University of Connecticut
- Current Assignee Address: NO Trondheim; US CT Farmington
- Agency: Cantor Colburn LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N7/00 ; C12N15/113 ; A61P25/28 ; C12N5/10
Abstract:
A delivery vehicle which comprises a nucleic acid construct, wherein the nucleic acid construct comprises (i) an enhancer which specifically drives gene expression in cells of the entorhinal cortex (ii) a promoter; and (iii) a therapeutic gene, wherein said enhancer, promoter and therapeutic gene are operatively linked, said enhancer and therapeutic gene are heterologous, and said delivery vehicle is suitable for delivery of the nucleic acid construct to the brain of a mammal.
Public/Granted literature
- US20190247516A1 NEURONAL ENHANCERS Public/Granted day:2019-08-15
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