An automatic field-of-view (FOV) prescription system is provided. The system includes an FOV prescription computing device that includes at least one processor electrically coupled to at least one memory device. The at least one processor is programmed to receive localizer images that depict an anatomy, and generate masks associated with the localizer images, wherein the masks represent part of the localizer images that depict the anatomy. The at least one processor is also programmed to calculate bounding boxes surrounding the anatomy based on the masks, generate an FOV based on the bounding boxes, and output the FOV.