Embodiments disclosed herein provide systems, methods, and computer readable media for a segmented video codec for high resolution and high frame rate video. In a particular embodiment, a method of encoding a composite video stream provides identifying a first portion of an image of a video stream for encoding using first parameters and a second portion of the image of the video stream for encoding using second parameters. The method further provides segmenting the first portion of the image into one or more first tiles and the second portion of the image into one or more second tiles. The method further provides encoding the first tiles using the first parameters and the second tiles using the second parameters and, after the encoding, combining the first tiles and the second tiles into the composite video stream.