Systems, methods, and non-transitory media are provided for capturing a region of interest (ROI) with a multi-camera system. An example method can include initializing image sensors of an electronic device, each image sensor being initialized in a lower-power mode having a lower power consumption than a higher-power mode supported by one or more of the image sensors; obtaining images captured by the image sensors in the lower-power mode; determining, based on the images, that an ROI in a scene is within a field-of-view (FOV) of a first image sensor from the image sensors; based on determining that the ROI is within the FOV of the first image sensor, decreasing the lower-power mode of one or more second image sensors to a power-off mode or an additional lower-power mode having a lower power consumption than the lower-power mode; and capturing, using the first image sensor, an image of the ROI.