Invention Grant
- Patent Title: Microfluidic devices and methods for purifying rare antigen-specific T cell populations
-
Application No.: US16347559Application Date: 2017-11-01
-
Publication No.: US11384327B2Publication Date: 2022-07-12
- Inventor: Songming Peng , James R. Heath , William Chour , Alphonsus Hon-Chung Ng , Sung Yang , Jongchan Choi , Ji-Chul Hyun
- Applicant: California Institute of Technology , Gwangju Institute of Science and Technology (GIST)
- Applicant Address: US CA Pasadena; KR Gwangju
- Assignee: California Institute of Technology,Gwangju Institute of Science and Technology (GIST)
- Current Assignee: California Institute of Technology,Gwangju Institute of Science and Technology (GIST)
- Current Assignee Address: US CA Pasadena; KR Gwangju
- Agency: Knobbe, Martens, Olson & Bear, LLP
- International Application: PCT/US2017/059598 WO 20171101
- International Announcement: WO2018/085453 WO 20180511
- Main IPC: C12M3/06
- IPC: C12M3/06 ; B01L3/00 ; G01N33/569 ; B01F25/433 ; B01F33/30

Abstract:
Disclosed herein are methods and devices for antigen-specific T cell identification or neoantigen identification. Also disclosed herein are devices for separating and isolating antigen-specific T cells or other particles of a certain size from a population of particles of different sizes. Also describe herein are methods and devices for the separation and isolation of barcoded T cells from other nanoparticles containing barcodes for subsequent analysis and further processing of a viable T cell.
Public/Granted literature
- US20200040293A1 MICROFLUIDIC DEVICES AND METHODS FOR PURIFYING RARE ANTIGEN-SPECIFIC T CELL POPULATIONS Public/Granted day:2020-02-06
Information query