公开(公告)号：US20240335803A1

公开(公告)日：2024-10-10

申请号：US18434638

申请日：2024-02-06

申请人： The University of British Columbia

发明人： Euan Ramsay ,  Robert James Taylor ,  Timothy Leaver ,  Andre Wild ,  Kevin Ou ,  Colin Walsh

IPC分类号： B01F25/431 ,  A61K9/16 ,  B01F25/432 ,  B01F25/433 ,  B01F33/30 ,  B01F33/81 ,  B01F101/22 ,  B01J19/00 ,  G01N15/00 ,  G01N35/00

CPC分类号： B01F25/43161 ,  A61K9/1682 ,  B01F25/4323 ,  B01F25/4331 ,  B01F33/30 ,  B01F33/813 ,  B01J19/0093 ,  B01F25/43172 ,  B01F25/431971 ,  B01F2101/22 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00855 ,  B01J2219/00858 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00894 ,  B01J2219/00898 ,  B01J2219/00986 ,  G01N2015/0038 ,  G01N2035/00158

摘要： The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

公开(公告)号：US12077638B2

公开(公告)日：2024-09-03

申请号：US15335184

申请日：2016-10-26

申请人： University of Wyoming

发明人： John Oakey ,  Kaspars Krutkramelis ,  Bingzhao Xia

IPC分类号： A61K36/9066 ,  A61K9/50 ,  A61K35/12 ,  A61L27/16 ,  A61L27/18 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  B01F23/41 ,  B01F25/433 ,  B01F33/3011 ,  B01J2/06 ,  B01J13/00 ,  B01J19/00 ,  C08F2/32 ,  C08F2/48 ,  C08J3/075 ,  C08J9/26 ,  C12N5/00 ,  C08F216/12 ,  C08F222/10

CPC分类号： C08J3/075 ,  A61K9/5026 ,  A61K35/12 ,  A61L27/16 ,  A61L27/18 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  B01F23/41 ,  B01F25/4331 ,  B01F33/3011 ,  B01J2/06 ,  B01J13/0052 ,  B01J19/0093 ,  C08F2/32 ,  C08F2/48 ,  C08J9/26 ,  C12N5/0012 ,  B01J2219/00792 ,  B01J2219/00936 ,  C08F216/125 ,  C08F222/102 ,  C08J2201/046 ,  C08J2205/022 ,  C08J2207/10 ,  C08J2335/02 ,  C08J2345/00

摘要： Provided herein are methods utilizing microfluidics for the oxygen-controlled generation of microparticles and hydrogels having controlled microparticle sizes and size distributions and products from provided methods. The included methods provide the generation of microparticles by polymerizing an aqueous solution dispersed in a non-aqueous continuous phase in an oxygen-controlled environment. The process allows for control of size of the size of the aqueous droplets and, thus, control of the size of the generated microparticles which may be used in biological applications.

公开(公告)号：US12076696B2

公开(公告)日：2024-09-03

申请号：US18230030

申请日：2023-08-03

申请人： Shibata Corporation

发明人： Yoshiki Shibata ,  Kouji Hanamura ,  Yoshitaka Sakamoto

IPC分类号： B01F23/00 ,  B01F23/20 ,  B01F23/231 ,  B01F25/40 ,  B01F25/431 ,  B01F25/432 ,  B01F25/433 ,  F15D1/02

CPC分类号： B01F23/23105 ,  B01F23/20 ,  B01F25/40 ,  B01F23/23112 ,  B01F25/4316 ,  B01F25/4323 ,  B01F25/4335 ,  F15D1/025

摘要： The purpose of the present disclosure is, in a bubble generating device provided with a bubble generating unit for generating minute bubbles in water flowing through the inside of the cylindrical main body unit, to improve the bubble generating efficiency of the bubble generating unit. Provided is a bubble generating device provided with a cylindrical main body unit and a bubble generating unit disposed within the main body, wherein: the bubble generating unit is provided with slits extending radially centered on one point within the main body unit in a cross-sectional plane of the main body unit, and a column part protruding from the inner peripheral surface of main body unit and formed on the peripheral edge of the slits; and the amount of protrusion of the column part is gradually reduced toward the upstream side from the peripheral edges of the slits, and the column part has a recessed part formed on the downstream surface.

公开(公告)号：US12072343B2

公开(公告)日：2024-08-27

申请号：US17062288

申请日：2020-10-02

申请人： Illumina, Inc.

发明人： Johanna L. Whitacre ,  Steven S. Phelps ,  Bradley Kent Drews ,  Debra Sue Bryan, II ,  Michael A. Niziolek ,  Joshua A. Darland ,  Umberto Ulmanella ,  Michael Dai Wang ,  Michelle L. Alvarez ,  Stephen Wayne Clark

IPC分类号： G01N35/10 ,  B01F23/40 ,  B01F23/45 ,  B01F25/10 ,  B01F25/433 ,  B01F31/65 ,  B01F33/84 ,  B01F35/53 ,  B01F35/71 ,  B01F35/75 ,  B01L3/00 ,  B01L3/02 ,  C12Q1/6874 ,  G01N35/00 ,  B01F101/23

CPC分类号： G01N35/1016 ,  B01F23/45 ,  B01F23/49 ,  B01F25/103 ,  B01F25/4331 ,  B01F31/651 ,  B01F33/84 ,  B01F35/53 ,  B01F35/7176 ,  B01F35/7544 ,  B01L3/0293 ,  B01L3/502 ,  B01L3/527 ,  C12Q1/6874 ,  G01N35/00584 ,  G01N35/1002 ,  G01N35/1097 ,  B01F2101/23 ,  B01L2200/0621 ,  B01L2200/16 ,  B01L2300/06 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0633 ,  B01L2400/086 ,  G01N2035/1058

摘要： A method includes, under control of control circuitry implementing a mixing protocol, aspirating reagents from multiple different reagent reservoirs into a cache channel. Designated amounts of the reagents are automatically aspirated from the corresponding reagent reservoirs by corresponding sippers based on the mixing protocol implemented by the control circuitry. The method also includes discharging the reagents from the cache channel into a mixing reservoir, and mixing the reagents within the mixing reservoir to form a reagent mixture.

公开(公告)号：US20240198299A1

公开(公告)日：2024-06-20

申请号：US18554586

申请日：2022-04-07

申请人： ROTAREX Solutions S.A.

发明人： Remy LOPES ,  Sergio LOPEZ ,  Isabelle SCHMITZ

IPC分类号： B01F23/232 ,  B01F25/312 ,  B01F25/433

CPC分类号： B01F23/2323 ,  B01F25/3121 ,  B01F25/31242 ,  B01F25/4337

摘要： The invention is directed to a nozzle (4) for mixing gas with liquid, comprising a body (8); a longitudinal passage (10) for the liquid, formed in the body (8) and with a portion (10.2) showing a reduced cross-section; at least one radial passage (12, 12.1, 12.2) for the gas, formed in the body (8) and opening out in the reduced cross-section portion (10.2); a liquid inlet port (14) formed in the body (8) and fluidly connected to the longitudinal passage (10); a gas inlet port (16) formed in the body (8) and fluidly connected to the at least one radial passage (12, 12.1, 12.2); wherein the gas inlet port (16) and the liquid inlet port (14) are arranged on a frontal transversal face (8.1) of the body (8).

公开(公告)号：US11921109B2

公开(公告)日：2024-03-05

申请号：US16543512

申请日：2019-08-16

申请人： Northeastern University ,  The General Hospital Corporation

发明人： Tania Konry ,  Martin L. Yarmush

IPC分类号： B01L3/00 ,  B01F25/433 ,  B01F33/30 ,  G01N21/64 ,  G01N33/53 ,  G01N33/543

CPC分类号： G01N33/54313 ,  B01F25/4331 ,  B01F33/30 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/502776 ,  G01N21/6428 ,  G01N33/5304 ,  G01N33/54366 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0487 ,  G01N2021/6439 ,  G01N2201/061

摘要： Microfluidic devices for use with reagents bound to microspheres for determination of the concentration of an analyte in a liquid sample are provided. The devices include two sequential mixing channels that promote rapid binding of microsphere-bound reagents with reagents in solution and a means for detecting labeled microsphere-bound reaction products. Also provided are methods for using the devices with microsphere-bound reagents to determine the concentration of an analyte in a liquid sample and to measure the binding affinity of antibody for an antigen.

公开(公告)号：US11844417B2

公开(公告)日：2023-12-19

申请号：US18170188

申请日：2023-02-16

申请人： Leon Trudeau

发明人： Leon Trudeau

IPC分类号： A46B11/00 ,  A46B11/06 ,  B01F5/04 ,  B01F5/06 ,  B01F15/04 ,  B01F3/04 ,  B01F23/235 ,  B01F23/20 ,  B01F25/316 ,  B01F25/433 ,  B01F35/88

CPC分类号： A46B11/0017 ,  A46B11/00 ,  A46B11/06 ,  B01F23/235 ,  B01F23/291 ,  B01F25/316 ,  B01F25/4336 ,  B01F35/88222 ,  A46B11/002 ,  A46B11/0062 ,  A46B2200/3033

摘要： A portable foam brush assembly having a base having a soap supply, a water supply, and an electrical supply. A foam brush wand is detachably dockable to the base and in electrical and fluid communication with the foam brush wand having battery pack, a peristaltic pump, a reservoir chamber, a foaming chamber, an air pump, a brush and a momentary release switch. The base water supply and the base soap supply, when activated, are configured to travel by a water supply hose and a soap supply hose to a tee in the base where they are combined in a combined hose to a base quick coupler that is connectable to a reciprocal foam brush wand quick coupler, which has a foam brush wand hose to deliver the water soap mixture to bladder in the foam brush wand.

公开(公告)号：US20230219043A1

公开(公告)日：2023-07-13

申请号：US18178965

申请日：2023-03-06

申请人： BIO-RAD LABORATORIES, INC.

发明人： Darren Roy LINK ,  John Brian HUTCHISON ,  Michael L. SAMUELS ,  Michael WEINER

IPC分类号： B01F23/41 ,  C40B50/08 ,  G01N33/50 ,  C40B40/04 ,  B01J19/00 ,  B01F25/433 ,  G01N15/14 ,  B01L3/00 ,  B01F33/3011 ,  B01L7/00 ,  B01F101/23 ,  G01N15/10

CPC分类号： B01F23/41 ,  C40B50/08 ,  G01N33/5008 ,  C40B40/04 ,  B01J19/0046 ,  B01F25/433 ,  G01N15/1459 ,  B01L3/502761 ,  B01F33/3011 ,  B01F25/4336 ,  B01L2400/0487 ,  B01L2300/0654 ,  B01J2219/00286 ,  B01J2219/00479 ,  B01L7/52 ,  B01L2300/0636 ,  B01J2219/0059 ,  B01J2219/00702 ,  B01L2200/027 ,  B01J2219/00599 ,  B01F2101/23 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00592 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01L2300/0864 ,  B01L2400/0415 ,  G01N2500/00 ,  B01J2219/00743 ,  B01J2219/0074 ,  B01L2300/0645 ,  B01J2219/00657 ,  B01J2219/00418 ,  B01J2219/00351 ,  B01L2300/0867 ,  B01J2219/0065 ,  B01L2300/0681 ,  G01N2015/1006 ,  B01J2219/00664 ,  Y02A90/10

摘要： The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.

公开(公告)号：US11517862B2

公开(公告)日：2022-12-06

申请号：US17036549

申请日：2020-09-29

申请人： TRUSVAL TECHNOLOGY CO., LTD.

发明人： Shih-Pao Chien ,  Yao-Tai Yang

IPC分类号： B01F25/30 ,  B01F23/40 ,  B01F35/80 ,  B01F25/10 ,  B01F25/313 ,  B01F23/451 ,  B01F25/433

摘要： A fluid mixing assembly includes a connecting cap, a three-way pipe and a connecting member; the connecting cap has a first connecting portion; the three-way pipe is connected to the connecting cap, and has a second connecting portion, an output portion and a cavity, wherein the second connecting portion, the output portion and the cavity communicate with each other; the connecting member is connected to the connecting cap, and has a pin-hole channel, wherein the pin-hole channel has a first end bore and a second end bore opposite to the first end bore, the first end bore communicates with the first connecting portion, and the second end bore communicates with the second connecting portion and the output portion.

公开(公告)号：US11478799B2

公开(公告)日：2022-10-25

申请号：US15926985

申请日：2018-03-20

申请人： The University of Chicago

发明人： Rustem F. Ismagilov ,  Joshua David Tice ,  Cory John Gerdts ,  Bo Zheng

IPC分类号： B01L3/00 ,  B01J19/00 ,  B82Y30/00 ,  G01N35/08 ,  B01F25/433 ,  B01F33/302 ,  G01N1/28 ,  B01D9/00 ,  C07K14/43 ,  C12N9/36 ,  C30B7/14 ,  C30B29/54 ,  C30B29/58 ,  B01J14/00 ,  C12Q1/6806

摘要： The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.