- 专利标题: Chemigenetic voltage indicators
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申请号: US16347765申请日: 2017-11-30
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公开(公告)号: US11385236B2公开(公告)日: 2022-07-12
- 发明人: Eric R. Schreiter , Luke D. Lavis , Ahmed Abdelfattah
- 申请人: HOWARD HUGHES MEDICAL INSTITUTE
- 申请人地址: US MD Chevy Chase
- 专利权人: HOWARD HUGHES MEDICAL INSTITUTE
- 当前专利权人: HOWARD HUGHES MEDICAL INSTITUTE
- 当前专利权人地址: US MD Chevy Chase
- 代理机构: Stites & Harbison, PLLC
- 代理商 Mandy Wilson Decker; Samuel A. Raque
- 国际申请: PCT/US2017/063998 WO 20171130
- 国际公布: WO2018/102577 WO 20180607
- 主分类号: G01N33/58
- IPC分类号: G01N33/58 ; C07K14/195 ; C07K14/215 ; C07K14/435 ; C07K14/46 ; C07K14/465 ; C12N9/14 ; G01N21/64 ; G01N33/566
摘要:
Provided herein are a voltage indicator and a method of measuring voltage. The voltage indicator includes a membrane-localized voltage-sensitive protein coupled to a capture protein. The method of measuring voltage includes administering a voltage indicator including a membrane-localized voltage-sensitive protein coupled to a capture protein, and determining changes in fluorescence of a small-molecule fluorescent dye captured by the capture protein.
公开/授权文献
- US20200025769A1 CHEMIGENETIC VOLTAGE INDICATORS 公开/授权日:2020-01-23
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