Methods, systems, and computer-readable media for processing policy variance requests in an enterprise computing environment are presented. A computing platform may receive, from a first endpoint computing device, a request for a first policy variance. In response to receiving the request, the computing platform may authenticate the first endpoint computing device based on enrollment information and may validate contents of the request. Subsequently, the computing platform may generate a policy variance result message based on approval or rejection of the request for the first policy variance. Then, the computing platform may send, to the first endpoint computing device, the policy variance result message. By sending the policy variance result message to the first endpoint computing device, the computing platform may cause the first endpoint computing device to execute a policy action corresponding to the approval or rejection of the request for the first policy variance.