Invention Grant
- Patent Title: Indazole derivatives and pharmaceutical composition for preventing, alleviating or treating cancer containing the same
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Application No.: US16897987Application Date: 2020-06-10
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Publication No.: US11407745B2Publication Date: 2022-08-09
- Inventor: Gyo Chang Keum , Ashraf Kareem El-Damasy , Hee Won Jin , Taek Kang , Eun Kyoung Bang
- Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Seoul
- Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Seoul
- Agency: Goldilocks Zone IP Law
- Priority: KR10-2019-0069242 20190612
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D403/12 ; C07D231/56 ; A61P35/02

Abstract:
Disclosed are a compound selected from novel indazole derivatives, pharmaceutically acceptable salts thereof, hydrates thereof and stereoisomers thereof, a method for preparing the compound, and a pharmaceutical composition for preventing, alleviating or treating cancer containing the compound as an active ingredient. The novel indazole derivatives exhibit excellent ABL/DDR1 inhibitory efficacy and anti-proliferative efficacy against cancer cells, specifically blood cancer cells, and inhibitory activity against ABL T315I point mutations, thus being useful for the prevention, alleviation or treatment of cancer, specifically blood cancer, especially chronic myelogenous leukemia.
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