公开(公告)号：US11407745B2

公开(公告)日：2022-08-09

申请号：US16897987

申请日：2020-06-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gyo Chang Keum ,  Ashraf Kareem El-Damasy ,  Hee Won Jin ,  Taek Kang ,  Eun Kyoung Bang

IPC: C07D413/12 ,  C07D403/12 ,  C07D231/56 ,  A61P35/02

Abstract: Disclosed are a compound selected from novel indazole derivatives, pharmaceutically acceptable salts thereof, hydrates thereof and stereoisomers thereof, a method for preparing the compound, and a pharmaceutical composition for preventing, alleviating or treating cancer containing the compound as an active ingredient. The novel indazole derivatives exhibit excellent ABL/DDR1 inhibitory efficacy and anti-proliferative efficacy against cancer cells, specifically blood cancer cells, and inhibitory activity against ABL T315I point mutations, thus being useful for the prevention, alleviation or treatment of cancer, specifically blood cancer, especially chronic myelogenous leukemia.