- 专利标题: Substituted piperidines as kinase inhibitors
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申请号: US16770213申请日: 2018-12-28
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公开(公告)号: US11407754B2公开(公告)日: 2022-08-09
- 发明人: In Woo Kim , Nam Youn Kim , Seung Hwarn Jeong , Bo-Kyoung Kim , Jun Hee Lee
- 申请人: Daewoong Pharmaceutical Co., Ltd.
- 申请人地址: KR Gyeonggi-do
- 专利权人: Daewoong Pharmaceutical Co., Ltd.
- 当前专利权人: Daewoong Pharmaceutical Co., Ltd.
- 当前专利权人地址: KR Gyeonggi-do
- 代理机构: Marshall, Gerstein & Borun LLP
- 优先权: KR10-2017-0183062 20171228
- 国际申请: PCT/KR2018/016813 WO 20181228
- 国际公布: WO2019/132561 WO 20190704
- 主分类号: A61K31/519
- IPC分类号: A61K31/519 ; C07D487/04
摘要:
The present invention relates to a compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, and the compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions: wherein, X1 is —NR1—, —O—, or —S—, X2 is CH or N, R1 is C1-5 alkyl, C3-6 cycloalkyl, CH2CHF2, or CH2CF3, wherein the C1-5 alkyl is optionally substituted with one NHC(O)OC(CH3)3 substituent, R2 is H, C1-5 alkyl, or halogen, and R3 is H or C1-5 alkyl.
公开/授权文献
- US20210188854A1 Amino-methyl Piperidine Derivative as Kinase Inhibitor 公开/授权日:2021-06-24
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