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    Substituted piperidines as kinase inhibitors
    7.
    发明授权
    Substituted piperidines as kinase inhibitors 有权

    公开(公告)号：US11407754B2

    公开(公告)日：2022-08-09

    申请号：US16770213

    申请日：2018-12-28

    申请人： Daewoong Pharmaceutical Co., Ltd.

    发明人： In Woo Kim ,  Nam Youn Kim ,  Seung Hwarn Jeong ,  Bo-Kyoung Kim ,  Jun Hee Lee

    IPC分类号： A61K31/519 ,  C07D487/04

    摘要： The present invention relates to a compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, and the compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions: wherein, X1 is —NR1—, —O—, or —S—, X2 is CH or N, R1 is C1-5 alkyl, C3-6 cycloalkyl, CH2CHF2, or CH2CF3, wherein the C1-5 alkyl is optionally substituted with one NHC(O)OC(CH3)3 substituent, R2 is H, C1-5 alkyl, or halogen, and R3 is H or C1-5 alkyl.

    Substituted piperidines as kinase inhibitors
    8.
    发明授权
    Substituted piperidines as kinase inhibitors 有权

    公开(公告)号：US11339167B2

    公开(公告)日：2022-05-24

    申请号：US16770638

    申请日：2018-12-28

    申请人： Daewoong Pharmaceutical Co., Ltd.

    发明人： In Woo Kim ,  Sun Ah Jun ,  Nam Youn Kim ,  Jun Hee Lee

    IPC分类号： A61K31/519 ,  C07D487/04

    摘要： The present invention relates to a compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, and the compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions: wherein: R1 is pyrazolyl, isooxazolyl, isothiazolyl, phenyl, or benzothiazolyl, wherein the pyrazolyl, isoxazolyl, isothiazolyl, phenyl, or benzothiazolyl is optionally substituted with one Ra substituent; R2 is H, halogen, CN, or C1-5 alkyl; and Ra is C1-5 alkyl, C1-5 haloalkyl, C1-5 hydroxyalkyl, C3-6 cycloalkyl, tetrahydropyranyl, piperidinyl, or morpholino.