- 专利标题： Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-HSV receptors
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申请号： US16417254申请日： 2019-05-20
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公开(公告)号： US11419926B2公开(公告)日： 2022-08-23
- 发明人: Joseph C. Glorioso, III , Hiroaki Uchida , Justus B. Cohen
- 申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education
- 申请人地址： US PA Pittsburgh
- 专利权人： University of Pittsburgh—Of the Commonwealth System of Higher Education
- 当前专利权人： University of Pittsburgh—Of the Commonwealth System of Higher Education
- 当前专利权人地址： US PA Pittsburgh
- 代理机构： Leydig, Voit & Mayer
- 主分类号： A61K35/763
- IPC分类号： A61K35/763 ; C12N15/869 ; C12N15/38 ; A61K48/00 ; A61K35/00 ; A61K39/00 ; C07K14/005 ; C12N7/00 ; C12N15/86
摘要：
In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising (a) a mutant gC and/or gD envelope glycoprotein which comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type; and (b) a mutant envelope glycoprotein other than gD.
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