Systems and methods for smart multi-zone control are provided. The system can include a plurality of sensors, a plurality of dampers, and a controller. The plurality of sensors can be configured to sense temperatures of a plurality of zones. The plurality of dampers can be configured to control the temperatures of the plurality of zones. The controller can be configured to obtain a first array associated with the plurality of sensors. Each element in the first array can represent a difference between a measurement value of a respective sensor and a setpoint associated with the respective sensor. The controller can be configured to obtain a second array associated with the plurality of dampers. Each element in the second array can represent a damper position of a respective damper. The controller can be configured to determine values of entries of a matrix using the first array and the second array.