Systems and methods are disclosed for secure predictors for speculative execution. Some implementations may eliminate or mitigate side-channel attacks, such as the Spectre-class of attacks, in a processor. For example, an integrated circuit (e.g., a processor) for executing instructions includes a predictor circuit that, when operating in a first mode, uses data stored in a set of predictor entries to generate predictions. For example, the integrated circuit may be configured to: detect a security domain transition for software being executed by the integrated circuit; responsive to the security domain transition, change a mode of the predictor circuit from the first mode to a second mode and invoke a reset of the set of predictor entries, wherein the second mode prevents the use of a first subset of the predictor entries of the set of predictor entries; and, after completion of the reset, change the mode back to the first mode.