A system for connection to a catheter to aspirate clot from the vasculature of a patient includes a vacuum console and a canister assembly which can be removably mounted in a mounting region of the vacuum console. The canister assembly includes a clear canister with an interior and an open top. A lid is removably attachable over the open top of the clear canister, and the clear canister has a vacuum port and a pressure sensing port each formed in a wall of the canister. The vacuum port aligns with a vacuum connector on the enclosure and the pressure sensing port aligns with a pressure sensing connector on the enclosure when the canister assembly is mounted on the mounting region of the vacuum console. The clear canister has a filter plate configured to be suspended in the interior of the clear canister at a location mid-way between the open top and a bottom to separate clot from blood as they are aspirated from the catheter.