Methods for capturing and transmitting images by an in-vivo device comprise operating a pixel array in a superpixel readout mode to capture probe image, for example, according to a time interval. Concurrently to capturing of each probe image, the probe image is evaluated alone or in conjunction with other probe image(s), and if it is determined that no event of interest is detected by the last probe image, or by the last few probe images, the pixel array is operated in the superpixel readout mode and a subsequent probe image is captured. However, if it is determined that the last probe image, or the last few probe images, detected an event of interest, the pixel array is operated in a single pixel readout mode and a single normal image, or a series of normal image, is captured and transmitted, for example, to an external receiver.