Invention Grant
![Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators](/docs/US/2022-09-20/US11447495B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators
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Application No.: US16325080Application Date: 2017-08-16
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Publication No.: US11447495B2Publication Date: 2022-09-20
- Inventor: Alexander E. Arnold , Douglas C. Stafford , James M. Cook , Charles W. Emala , Gloria Forkuo , Rajwana Jahan , Revathi Kodali , Guanguan Li , Michael Rajesh Stephen
- Applicant: UWM Research Foundation, Inc. , The Trustees of Columbia University in the City of New York
- Applicant Address: US WI Milwaukee; US NY New York
- Assignee: UWM Research Foundation, Inc.,The Trustees of Columbia University in the City of New York
- Current Assignee: UWM Research Foundation, Inc.,The Trustees of Columbia University in the City of New York
- Current Assignee Address: US WI Milwaukee; US NY New York
- Agency: Michael Best & Friedrich LLP
- International Application: PCT/US2017/047185 WO 20170816
- International Announcement: WO2018/035246 WO 20180222
- Main IPC: A61K31/5517
- IPC: A61K31/5517 ; C07D487/04 ; C07D487/14 ; A61P11/06
![Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators](/abs-image/US/2022/09/20/US11447495B2/abs.jpg.150x150.jpg)
Abstract:
Substituted benzo[f]imidazo[1,5-α][1,4]diazepines of formula (I′) target alpha-4 and alpha-5 GABAA receptors for use in the treatment of airway hyperresponsiveness and inflammation in asthma. Compounds selectively partition to the peripheral compartment and have reduced CNS effects.
Public/Granted literature
- US20210284649A1 GABA(A) RECEPTOR MODULATORS AND METHODS TO CONTROL AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN ASTHMA Public/Granted day:2021-09-16
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