公开(公告)号：US20240350267A1

公开(公告)日：2024-10-24

申请号：US18663189

申请日：2024-05-14

申请人： Icahn School of Medicine at Mount Sinai ,  The Trustees of Columbia University in the City of New York

发明人： Gilbert H.L. Tang ,  Vinayak Bapat ,  Susheel K. Kodali

IPC分类号： A61F2/24 ,  A61B17/00 ,  A61F2/95

CPC分类号： A61F2/2436 ,  A61F2/2466 ,  A61F2/9517 ,  A61B2017/00243 ,  A61B2017/00367 ,  A61F2210/0014 ,  A61F2250/0098

摘要： A delivery system for a transcatheter heart valve (THV) to a subject is provided, the delivery system includes a delivery catheter housing the THV therein; an elongated member for receiving the THV thereon and having an accessory extending from the distal portion thereof, the accessory comprising a plurality of components for alignment with commissures of the THV during delivery of the THV, and a rotational member connected to the elongated member to rotate the accessory and THV together to align with a native or bioprosthetic valve commissure or valve leaflet at a desired angle.

公开(公告)号：US20240335428A1

公开(公告)日：2024-10-10

申请号：US18627405

申请日：2024-04-04

申请人： Baylor University ,  The Trustees of Columbia University in the City of New York

发明人： Daniel Romo ,  Kenneth G. Hull ,  Haoran Xue ,  Mingzhao Zhu ,  Susan E. Bates ,  Maryam Safari ,  Antonio Fojo

IPC分类号： A61K31/429 ,  A61K9/00 ,  A61P35/00

CPC分类号： A61K31/429 ,  A61K9/0019 ,  A61P35/00

摘要： Method for treating pancreatic cancer using des-methyl pateamine A (DMPatA) or a pharmaceutically acceptable salt thereof, or des-methyl des-amino pateamine A (DMDAPatA) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240326017A1

公开(公告)日：2024-10-03

申请号：US18621503

申请日：2024-03-29

申请人： UT-Battelle, LLC ,  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  Cornell University

发明人： Michelle K. Kidder ,  Ah-Hyung Park ,  Yong L. Joo

IPC分类号： B01J20/28 ,  B01D39/16 ,  B01D53/02 ,  B01D53/62 ,  B01J20/22 ,  B01J20/26 ,  D01F8/16 ,  D01F8/18

CPC分类号： B01J20/28023 ,  B01D39/1623 ,  B01D53/02 ,  B01D53/62 ,  B01J20/223 ,  B01J20/262 ,  B01J20/264 ,  D01F8/16 ,  D01F8/18 ,  B01D2239/0216 ,  B01D2239/0407 ,  B01D2239/0428 ,  B01D2239/0631 ,  B01D2257/504 ,  B01D2258/0283 ,  B01J2220/445 ,  B01J2220/46

摘要： An encapsulated fiber composition (typically resulting from an electrospinning process) containing: (i) a lengthwise core portion of the fiber comprising an amine-containing material for adsorbing carbon dioxide; and (ii) a lengthwise sheath portion of the fiber surrounding said lengthwise core portion, wherein the lengthwise sheath portion comprises a microporous polymer. Particularly described are fiber compositions containing a nanoparticle organic hybrid material (NOHM) or organoamine or amine-containing sorbent (e.g., PEI or TEPA) in a core portion of the fiber and a polymer of intrinsic microporosity (PIM), such as PIM-1 or PIM-2, or PAN or PAN combined with a polysilazane or polysiloxane in a sheath portion of the fiber. A method of using the fiber composition to capture carbon dioxide, such as from ambient air, is also described.

公开(公告)号：US20240325794A1

公开(公告)日：2024-10-03

申请号：US18625639

申请日：2024-04-03

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Elisa E. Konofagou ,  Alec J. Batts ,  Alina R. Kline-Schoder

IPC分类号： A61N7/02 ,  A61N7/00

CPC分类号： A61N7/02 ,  A61N2007/0021 ,  A61N2007/0039

摘要： The present subject matter relates to techniques for releasing extracellular vesicles. The disclosed system can include an ultrasound assembly configured to apply an ultrasound treatment to a target tissue of the subject, a sampling device configured to collect a sample from the subject, and an analysis device configured to analyze a biomarker in the sample. The ultrasound assembly can include an ultrasound transducer and a function generator.

公开(公告)号：US20240318218A1

公开(公告)日：2024-09-26

申请号：US18610436

申请日：2024-03-20

申请人： The Trustees of Columbia University in The City of New York

发明人： Scott BANTA ,  Emma WILLETT

IPC分类号： C12P19/30

CPC分类号： C12P19/30

摘要： Synthetic enzymatic cascades are provided that continuously produce adenosine triphosphate (ATP) from a variety of fuel sources. The cascades are prepared by expressing one or more NADH-dependent dehydrogenases, polyphosphate NAD+ kinases (PPNK), NADPH oxidases, and particular reversible ATP-NAD+ kinases (NADK). The NADH-dependent dehydrogenases oxidize fuel sources such as formate and methanol while converting NAD+ to NADH. The PPNKs convert the NADH to NADPH. The NADPH oxidases convert NADPH to NADP+. The NADKs then convert the NADP+ to NAD+ while also facilitating conversion of adenosine diphosphate (ADP) or adenosine monophosphate (AMP) to ATP. Human NADK exhibits high affinity for NAD+ and is thus impeded in the generation of ATP products via product inhibition. Thus, pigeon, duck, and cat NADK isoforms are implemented in the cascade instead. The cascades generate a low-cost, continuous source ATP product for use in numerous in vitro applications such as cell-free protein production.

公开(公告)号：US12098187B2

公开(公告)日：2024-09-24

申请号：US16770840

申请日：2018-12-20

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： David D. Ho ,  Yaoxing Huang ,  Jian Yu

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61P31/18 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61P31/18 ,  C07K16/2812 ,  C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/567 ,  C07K2317/66 ,  C07K2317/76 ,  C07K2317/94

摘要： In various embodiments, the present invention relates generally to using bispecific antibodies in the prevention and treatment of HIV.

公开(公告)号：US12097037B2

公开(公告)日：2024-09-24

申请号：US16624452

申请日：2018-06-20

申请人： The Trustees of Columbia University in the City of New York ,  The Nathan S. Kline Institute for Psychiatric Research

发明人： Daniel Javitt ,  Antigona Martinez ,  Yaakov Stern

IPC分类号： A61B5/378 ,  A61B5/00 ,  A61B5/374

CPC分类号： A61B5/378 ,  A61B5/374 ,  A61B5/4088 ,  A61B5/7257

摘要： An exemplary system, method, and computer-accessible medium for generating diagnostic data associated with a likelihood a patient(s) developing a mental disease(s) can be provided, which can include, for example, providing a visual patterns to the patient(s), receiving electroencephalogram (EEG) information from the patient(s) that can be based on the visual pattern(s); and generating the diagnostic data based on the EEG information.

公开(公告)号：US20240307449A1

公开(公告)日：2024-09-19

申请号：US18671626

申请日：2024-05-22

申请人： The Trustees of Columbia University in the City of New York

发明人： Alana NGUYEN ,  Michael M. SHEN

IPC分类号： A61K35/17 ,  A61P35/00 ,  C12N5/0783 ,  C12N5/09 ,  C12Q1/6869 ,  G01N33/50

CPC分类号： A61K35/17 ,  A61P35/00 ,  C12N5/0636 ,  C12N5/0693 ,  C12Q1/6869 ,  G01N33/5011 ,  C12N2501/2302 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2502/1114 ,  C12N2502/1157

摘要： The invention discloses a method to co-culture patient-derived tumor organoids and the corresponding patient's tumor-infiltrating lymphocytes from a tumor sample.

公开(公告)号：US20240302157A1

公开(公告)日：2024-09-12

申请号：US18509739

申请日：2023-11-15

申请人： The Trustees of Columbia University in the City of New York

发明人： Michal Lipson ,  Xingchen Ji ,  Alexander Klenner ,  Xinwen Yao ,  Yu Gan ,  Alexander L. Gaeta ,  Christine P. Hendon

IPC分类号： G01B9/02001 ,  G01B9/02091

CPC分类号： G01B9/02008 ,  G01B9/02091

摘要： A method of providing optical coherence tomography (OCT) imaging may comprise using an on-chip frequency comb source interfaced with an OCT system by a circulator as an imaging source and reconstructing OCT images from resulting spectral data from target tissue illuminated by the imaging source.

公开(公告)号：US12077547B2

公开(公告)日：2024-09-03

申请号：US18046205

申请日：2022-10-13

申请人： The Trustees of Columbia University in the City of New York

发明人： Andrew Wasmuth ,  Donald W. Landry

IPC分类号： C07D495/04 ,  A61P9/10 ,  A61P13/12 ,  A61P17/00 ,  A61P25/02

CPC分类号： C07D495/04 ,  A61P9/10 ,  A61P13/12 ,  A61P17/00 ,  A61P25/02

摘要： The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.