Invention Grant
- Patent Title: TNF-targeting aptamers and uses thereof for treatment or diagnosing TNF-related inflammatory diseases
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Application No.: US17049048Application Date: 2018-12-21
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Publication No.: US11447778B2Publication Date: 2022-09-20
- Inventor: Pan-Chyr Yang , Wei-Yun Lai , Jen-Wei Wang
- Applicant: Academia Sinica , National Taiwan University
- Applicant Address: TW Taipei; TW Taipei
- Assignee: Academia Sinica,National Taiwan University
- Current Assignee: Academia Sinica,National Taiwan University
- Current Assignee Address: TW Taipei; TW Taipei
- Agency: Amin, Turocy & Watson, LLP
- International Application: PCT/US2018/067140 WO 20181221
- International Announcement: WO2019/203904 WO 20191024
- Main IPC: C12N15/115
- IPC: C12N15/115 ; A61K47/60 ; G01N33/53
Abstract:
Nucleic acid aptamers that bind to tumor necrosis factor alpha (TNF). Also provided herein are pharmaceutical compositions comprising such anti-TNF aptamers and methods for the using the same for therapeutic and diagnostic applications, for example, alleviating liver injury and monitoring presence of TNF in vivo or in vitro.
Public/Granted literature
- US20210254072A1 TNF-TARGETING APTAMERS AND USES THEREOF FOR TREATMENT OR DIAGNOSING TNF-RELATED INFLAMMATORY DISEASES Public/Granted day:2021-08-19
Information query
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