Invention Grant
- Patent Title: Method for identifying a modulator of the TNFα or CD40L interaction with their cognate receptors
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Application No.: US16883859Application Date: 2020-05-26
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Publication No.: US11448655B2Publication Date: 2022-09-20
- Inventor: James Philip O'Connell , John Robert Porter , Alastair Lawson , Boris Kroeplien , Stephen Edward Rapecki , Timothy John Norman , Graham John Warrellow
- Applicant: UCB BIOPHARMA SRL
- Applicant Address: BE Brussels
- Assignee: UCB BIOPHARMA SRL
- Current Assignee: UCB BIOPHARMA SRL
- Current Assignee Address: BE Brussels
- Agency: Medler Ferro Woodhouse & Mills
- Priority: GB1510758 20150618
- Main IPC: G01N33/68
- IPC: G01N33/68 ; C07K14/525 ; C07K16/24 ; A61K47/64 ; A61P37/00 ; A61P35/00 ; C07D401/14 ; C07D471/00 ; C07K14/705 ; C07D213/72 ; C07D235/04 ; C07D239/26 ; C07D471/04
Abstract:
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.
Information query
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