- 专利标题： Method for identifying a modulator of the TNFα or CD40L interaction with their cognate receptors
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申请号： US16883859申请日： 2020-05-26
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公开(公告)号： US11448655B2公开(公告)日： 2022-09-20
- 发明人: James Philip O'Connell , John Robert Porter , Alastair Lawson , Boris Kroeplien , Stephen Edward Rapecki , Timothy John Norman , Graham John Warrellow
- 申请人： UCB BIOPHARMA SRL
- 申请人地址： BE Brussels
- 专利权人： UCB BIOPHARMA SRL
- 当前专利权人： UCB BIOPHARMA SRL
- 当前专利权人地址： BE Brussels
- 代理机构： Medler Ferro Woodhouse & Mills
- 优先权： GB1510758 20150618
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; C07K14/525 ; C07K16/24 ; A61K47/64 ; A61P37/00 ; A61P35/00 ; C07D401/14 ; C07D471/00 ; C07K14/705 ; C07D213/72 ; C07D235/04 ; C07D239/26 ; C07D471/04
摘要：
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.
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