- 专利标题: Salt of an aminopyridine derivative compound, a crystalline form thereof, and a process for preparing the same
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申请号: US16605944申请日: 2018-04-18
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公开(公告)号: US11453656B2公开(公告)日: 2022-09-27
- 发明人: Sang Ho Oh , Jong Gyun Kim , Se-Woong Oh , Tae Dong Han , Soo Yong Chung , Seong Ran Lee , Kyeong Bae Kim , Young Sung Lee , Woo Seob Shin , Hyun Ju , Jeong Ki Kang , Su Min Park , Dong Kyun Kim
- 申请人: Yuhan Corporation
- 申请人地址: KR Seoul
- 专利权人: Yuhan Corporation
- 当前专利权人: Yuhan Corporation
- 当前专利权人地址: KR Seoul
- 代理机构: BakerHostetler
- 优先权: KR10-2017-0051687 20170421
- 国际申请: PCT/KR2018/004473 WO 20180418
- 国际公布: WO2018/194356 WO 20181025
- 主分类号: C07C309/04
- IPC分类号: C07C309/04 ; C07C303/22 ; C07C403/04 ; C07D403/04
摘要:
The present invention relates to novel mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yppyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, a novel crystalline form thereof, and a process for preparing the same. More specifically, the present invention relates to mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, which is excellent in stability, solubility, and bioavailability when it is administered not only alone but also in combination with other drugs and which has a high purity, a crystalline form thereof, and a process for preparing the same.
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