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公开(公告)号:US11981659B2
公开(公告)日:2024-05-14
申请号:US17697655
申请日:2022-03-17
申请人: Yuhan Corporation
发明人: Sang Ho Oh , Jong Gyun Kim , Se-Woong Oh , Tae Dong Han , Soo Yong Chung , Seong Ran Lee , Kyeong Bae Kim , Young Sung Lee , Woo Seob Shin , Hyun Ju , Jeong Ki Kang , Su Min Park , Dong Kyun Kim
IPC分类号: C07D403/04 , C07C303/22 , C07C309/04
CPC分类号: C07D403/04 , C07C303/22 , C07C309/04 , C07B2200/13
摘要: The present invention relates to novel mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, a novel crystalline form thereof, and a process for preparing the same. More specifically, the present invention relates to mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, which is excellent in stability, solubility, and bioavailability when it is administered not only alone but also in combination with other drugs and which has a high purity, a crystalline form thereof, and a process for preparing the same.
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公开(公告)号:US11453656B2
公开(公告)日:2022-09-27
申请号:US16605944
申请日:2018-04-18
申请人: Yuhan Corporation
发明人: Sang Ho Oh , Jong Gyun Kim , Se-Woong Oh , Tae Dong Han , Soo Yong Chung , Seong Ran Lee , Kyeong Bae Kim , Young Sung Lee , Woo Seob Shin , Hyun Ju , Jeong Ki Kang , Su Min Park , Dong Kyun Kim
IPC分类号: C07C309/04 , C07C303/22 , C07C403/04 , C07D403/04
摘要: The present invention relates to novel mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yppyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, a novel crystalline form thereof, and a process for preparing the same. More specifically, the present invention relates to mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, which is excellent in stability, solubility, and bioavailability when it is administered not only alone but also in combination with other drugs and which has a high purity, a crystalline form thereof, and a process for preparing the same.
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