Systems and methods for managing content delivery functionalities based on machine learning models are provided. In one aspect, content requests are routed in accordance with clusters of historical content requests to optimize cache performance. In another aspect, content delivery strategies for responding to content requests are determined based on a model trained on data related to historical content requests. The model may also be used to determine above-the-fold configurations for rendering responses to content requests. In some embodiments, portions of the model can be executed on client computing devices.