Invention Grant
- Patent Title: 3′ end caps, 5′ end caps and combinations thereof for therapeutic RNA
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Application No.: US16802014Application Date: 2020-02-26
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Publication No.: US11466048B2Publication Date: 2022-10-11
- Inventor: David Barnes-Seeman , Scott Louis Cohen , John Louis Diener , Christian Gampe , James Roache , Amy White , Sarah Louise Williams , Jun Yuan , Frederic Zecri
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Jana A. Dailey
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07F9/6561 ; C07H19/167 ; C07H19/207 ; C07K14/575
Abstract:
The disclosure relates to nucleic acids that contain modifications at the 5′-end, 3′-end or 5′-end and 3′-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.
Information query
