A system for detecting and neutralizing a target aerial vehicle comprises a counter-attack unmanned aerial vehicle (UAV) comprising a flight body and a flight control system supported about the flight body operable to facilitate flight of the UAV, and an aerial vehicle countermeasure supported by the flight body. The system can comprise an aerial vehicle detection system comprising at least one detection sensor operable to detect a target aerial vehicle while in-flight, and operable to provide command data to the counter-attack UAV to facilitate interception of the target aerial vehicle by the counter-attack UAV. Upon interception of the target aerial vehicle, the counter-attack UAV is operable to disrupt operation of the detected target aerial vehicle with the aerial vehicle capture countermeasure, thereby neutralizing the target aerial vehicle. The counter-attack UAV and systems may be autonomously operated. Associated systems and methods are provided.