A system for automatically assessing orthostatic hypotension for a patient supported on a patient support apparatus. The system receives position data identifying a first position of a patient supported on a patient support apparatus, and after a delay, receives vital signs data of the patient. The system receives position data identifying a second position of the patient supported on the patient support apparatus, and after a delay, receives vital signs data of the patient. The system determines an orthostatic hypotension assessment based on a difference in the vital signs data between the first and second positions. Based on the orthostatic hypotension assessment, the system modifies one or more conditions on the patient support apparatus to mitigate a risk for patient fall.