Pneumatic and therapeutic compression systems are disclosed including treatment protocols that may be used with such systems. A pneumatic compression system may include a source and sink of a pressurizing fluid. The pressurizing fluid may be sourced to a number of valves, each valve controllable by a control device including a computing device. The computing device may control each valve separately to allow any one or more of the valves to connect to the fluid source or the fluid sink. The computing device may include one or more therapeutic protocols that may direct one, two, or more valves to switch between fluid sourcing and fluid sinking, substantially simultaneously or in a sequence. A therapeutic compression system may include the pneumatic system in fluid communication with an inflation sleeve composed of multiple cells. Each cell may be inflated or deflated by a valve according to the therapeutic protocol.