A method and apparatus that detect wheel misalignment are provided. The method includes predicting a self-aligning torque parameter based on a regression model determined from a dataset including one or more from among a steering wheel angle parameter, a speed parameter, a torsion bar torque parameter, a lateral acceleration parameter, and a power steering torque parameter, comparing a measured self-aligning torque parameter and the predicted self-aligning torque parameter, and outputting a wheel alignment condition indicating whether the wheel alignment is proper if the self-aligning torque parameter and the predicted self-aligning torque parameter are within a predetermined value based on the comparing.