Invention Grant
- Patent Title: Antibody constructs for CDH19 and CD3
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Application No.: US16040927Application Date: 2018-07-20
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Publication No.: US11498964B2Publication Date: 2022-11-15
- Inventor: Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan , Peter Kufer , Ralf Lutterbüse , Tobias Raum , Patrick Hoffmann , Doris Rau , Roman Kischel , Bryan Lemon , Holger Wesche
- Applicant: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
- Applicant Address: DE Munich; US CA Thousand Oaks
- Assignee: AMGEN RESEARCH (MUNICH) GMBH,AMGEN INC.
- Current Assignee: AMGEN RESEARCH (MUNICH) GMBH,AMGEN INC.
- Current Assignee Address: DE Munich; US CA Thousand Oaks
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/30 ; A61K47/60 ; C07K16/46 ; A61K39/00

Abstract:
The invention provides a bispecific antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention provides a nucleic acid encoding the antibody construct, a vector comprising the nucleic acid and a host cell transformed or transfected with the vector. Furthermore, the invention provides a process for the production of the bispecific antibody construct, a medical use of the antibody construct and a kit comprising the antibody construct. The bispecific antibody construct may be useful in the treatment of melanoma.
Public/Granted literature
- US20190016805A1 ANTIBODY CONSTRUCTS FOR CDH19 AND CD3 Public/Granted day:2019-01-17
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