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公开(公告)号：US20170129961A1
公开(公告)日：2017-05-11
申请号：US15225282
申请日：2016-08-01
发明人： Tobias Raum , Claudia Blümel , Wibke Deisting , Patrick Hoffmann , Ralf Lutterbüse , Elisabeth Nahrwold , Olivier Nolan-Stevaux , Marc Panzer
CPC分类号： C07K16/2875 , C07K16/2809 , C07K16/3069 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human CD70 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20210284748A1
公开(公告)日：2021-09-16
申请号：US17084088
申请日：2020-10-29
发明人： Tobias Raum , Claudia Blümel , Wibke Deisting , Patrick Hoffmann , Ralf Lutterbüse , Elisabeth Nahrwold , Olivier Nolan-Stevaux , Marc Panzer
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human CD70 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20240010724A1
公开(公告)日：2024-01-11
申请号：US17933277
申请日：2022-09-19
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan , Peter Kufer , Ralf Lutterbüse , Tobias Raum , Patrick Hoffmann , Doris Rau , Roman Kischel , Bryan Lemon , Holger Wesche
CPC分类号： C07K16/2809 , C07K16/28 , C07K16/3053 , A61K2039/505 , C07K16/2896 , C07K16/468 , A61K47/60
摘要： The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US11498964B2
公开(公告)日：2022-11-15
申请号：US16040927
申请日：2018-07-20
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan , Peter Kufer , Ralf Lutterbüse , Tobias Raum , Patrick Hoffmann , Doris Rau , Roman Kischel , Bryan Lemon , Holger Wesche
摘要： The invention provides a bispecific antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention provides a nucleic acid encoding the antibody construct, a vector comprising the nucleic acid and a host cell transformed or transfected with the vector. Furthermore, the invention provides a process for the production of the bispecific antibody construct, a medical use of the antibody construct and a kit comprising the antibody construct. The bispecific antibody construct may be useful in the treatment of melanoma.
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公开(公告)号：US10851170B2
公开(公告)日：2020-12-01
申请号：US15225282
申请日：2016-08-01
发明人： Tobias Raum , Claudia Blümel , Wibke Deisting , Patrick Hoffmann , Ralf Lutterbüse , Elisabeth Nahrwold , Olivier Nolan-Stevaux , Marc Panzer
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human CD70 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US10059766B2
公开(公告)日：2018-08-28
申请号：US14761839
申请日：2014-01-27
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan , Peter Kufer , Ralf Lutterbüse , Tobias Raum , Patrick Hoffmann , Doris Rau , Roman Kischel , Bryan Lemon , Holger Wesche
摘要： The invention provides a bispecific antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention provides a nucleic acid encoding the antibody construct, a vector comprising the nucleic acid and a host cell transformed or transfected with the vector. Furthermore, the invention provides a process for the production of the bispecific antibody construct, a medical use of the antibody construct and a kit comprising the antibody construct. The bispecific antibody construct may be useful in the treatment of melanoma.
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公开(公告)号：US09765157B2
公开(公告)日：2017-09-19
申请号：US14815861
申请日：2015-07-31
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , Peter Kufer , Patrick Hoffmann , Tobias Raum , Ralf Lutterbüse , Elisabeth Nahrwold , Claudia Blumel
CPC分类号： C07K16/468 , A61K47/60 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The present invention provides a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds a human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct in the treatment of melanoma, and a kit comprising the antibody construct.
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公开(公告)号：US20200071405A1
公开(公告)日：2020-03-05
申请号：US16570129
申请日：2019-09-13
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan , Peter Kufer , Ralf Lutterbüse , Tobias Raum , Patrick Hoffmann , Doris Rau , Roman Kischel , Bryan Lemon , Holger Wesche
摘要： The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20190016805A1
公开(公告)日：2019-01-17
申请号：US16040927
申请日：2018-07-20
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , M. Shawn Jeffries , Chadwick Terence King , Brian Mingtung Chan , Peter Kufer , Ralf Lutterbüse , Tobias Raum , Patrick Hoffmann , Doris Rau , Roman Kischel , Bryan Lemon , Holger Wesche
摘要： The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20180002450A1
公开(公告)日：2018-01-04
申请号：US15673539
申请日：2017-08-10
发明人： Shouhua Xiao , Zheng Pan , Dineli Wickramasinghe , Peter Kufer , Patrick Hoffmann , Tobias Raum , Ralf Lutterbüse , Elisabeth Nahrwold , Claudia Blumel
CPC分类号： C07K16/468 , A61K47/60 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The present invention provides to a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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