Systems and methods to disconnect a faulted region of a power grid are described. For example, a control system may obtain a set of regions of a power grid. The control system may obtain a current magnitude and a voltage magnitude of the power grid. The control system may detect a fault in the power grid based at least in part on the current magnitude. The control system may, from the set of regions, determine a faulted region that the fault is located within based on a voltage magnitude of one or more buses in the power grid, a net change in power with respect to time of one or more regions in the set of regions, or both. The control system may send one or more signals to electrically disconnect the faulted region from the power grid.