A multiple interface data exchange system utilizes a persistent in-memory storage in asynchronous data communication with a plurality of interfaces. Each interface is configured to communicate with at least one application using a particular communication protocol. The persistent in-memory storage stores tuple data sets received from applications transmitting data to the connected interface in a canonical (universal) format, automatically creating new tuples and updating existing tuples. The canonical format of the data is quickly queried in the persistent in-memory storage and available to other applications in connection with the multiple interface data exchange system regardless of the communication protocol used by a requesting application.