The application relates to maintaining time-synchronization of a wireless connection between a network access node and a client device. The wireless connection may be configured for services with latency constraints. In one example, based on an expiry of a time alignment timer for the client device, the network access node transmits a control message to the client device. The control message instructs the client device to transmit a response signal to the network access node. The response signal can be used by the network access node to determine the timing advance for the wireless connection and adjust the timing advance.