- 专利标题： Fibronectin type III domain proteins with enhanced solubility
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申请号： US16999291申请日： 2020-08-21
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公开(公告)号： US11512124B2公开(公告)日： 2022-11-29
- 发明人: Aaron P. Yamniuk , Stanley R. Krystek
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： US NJ Princeton
- 代理机构： Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Christopher L. Frank
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; C07K14/78
摘要：
Provided herein are polypeptides comprising a modified fibronectin type III (Fn3) domain, wherein the amino acid corresponding to residue 58 of SEQ ID NO: 1 is mutated, and wherein the solubility is enhanced relative to the solubility of a Fn3 domain in which the amino acid corresponding to residue 58 of SEQ ID NO: 1 is not mutated. Also provided are libraries comprising a plurality of the polypeptides and a method for identifying a polypeptide that binds to a target.
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