- 专利标题： Diverse carbene transferase enzyme catalysts derived from a P450 enzyme
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申请号： US17200394申请日： 2021-03-12
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公开(公告)号： US11525123B2公开(公告)日： 2022-12-13
- 发明人: Kai Chen , Noah P. Dunham , Daniel J. Wackelin , Andrew Z. Zhou , Zhen Liu
- 申请人： California Institute of Technology
- 申请人地址： US CA Pasadena
- 专利权人： California Institute of Technology
- 当前专利权人： California Institute of Technology
- 当前专利权人地址： US CA Pasadena
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 主分类号： C12N9/02
- IPC分类号： C12N9/02 ; C12P17/04 ; C12P7/62 ; C12P17/16
摘要：
The present disclosure provides cytochrome P450 variants useful for carrying out in vivo and in vitro carbene insertion reactions. Methods for preparing carbene insertion products including cyclopropenes, cyclopropanes, bicyclobutanes, substituted lactones, cyclized compounds, and substituted amines are also described.
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